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Magnetic Resonance Imaging Shows Specific Abnormalities in the MELAS Syndrome Neurol 41:1043-1046, Matthews,P.M., 1991 See this aricle in Pubmed Article Abstract The MELAS syndrome(mitochondrial myopathy,encephalopathy,lactic acidosis, and stroke-like episodes)can be difficult to identify.We report MRI abnormalities that we believe are specific to this disorder in three patients with complete or partial MELAS syndrome.The patients all showed an unusual pattern on T2-weighted MRI with multifocal areas of hyperintense signal confined to the cortex of the cerebrum,cerebellum,and immediately adjacent white matter.Some images suggested selective cortical involvement of deeper layers only.Deep white matter was relatively spared, distinguishing this from usual cerebrovascular disease or the edema after status epilepticus.Specificity of these findings is further suggested by a good correlation of these findings with the previously described unique postmortem brain pathology of MELAS.

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(click to filter results - removes previous filter) cerebellar atrophy,secondary cerebellar degeneration cerebral cortex gray matter MELAS syndrome MRI MRI,abnormal occipital lobe,infarction occipital lobe,lesion of

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